![]() ![]() Here, we extracted the chemical characteristics and sequential arrangement along a protein chain at the segmental level from natural protein libraries and used the information to design heteropolymer ensembles as mixtures of disordered, partially folded and folded proteins. We propose that in addition to the known monomeric sequence requirements, protein sequences encode multi-pair interactions at the segmental level to navigate random encounters 5, 6 synthetic heteropolymers capable of emulating such interactions can replicate how proteins behave in biological fluids individually and collectively. Despite these uncertainties, proteins fluctuate, fold, function and evolve as programmed 2, 3, 4. ![]() Biological fluids, the most complex blends, have compositions that constantly vary and cannot be molecularly defined 1.
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